Paper

1,2,4-Triazino-[5,6b]indole derivatives: effects of the trifluoromethyl group on in vitro antimalarial activity.

Published Apr 15, 2005 · J. Kgokong, Peter J. Smith, G. Matsabisa

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Trifluoromethyl-1,2,4-triazino[5,6b]indole derivatives with a trifluoromethyl group at position 6 show increased in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falcip

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

1,2,4-Triazino-[5,6b]indole derivatives: effects of the trifluoromethyl group on in vitro antimalarial activity.

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