New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via alpha,alpha-difluoro-alpha-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus and A. fumigatus in vitro and against C. albicans in vivo for oral and i.v. administrations. Especially, (-)-2a, (-)-2b and (-)-2d showed potent antifungal activities.

New 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety show potent antifungal activities against Candida albicans, C. krusei, A. flavus, and A. fumigatus in vitro and in

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New antifungal 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety.

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