A 1:2-dihydro-s-triazine with marked activity against certain pathogenic bacteria and synergistic with a sulphonamide in experimental bacterial infections.

doi:10.1016/0006-2952(59)90003-6

Paper

A 1:2-dihydro-s-triazine with marked activity against certain pathogenic bacteria and synergistic with a sulphonamide in experimental bacterial infections.

Published Dec 1, 1959 · M. W. Fisher, L. Doub

Biochemical pharmacology

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7

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

The dihydro-s-triazine shows marked activity against certain pathogenic bacteria and is synergistic with sulfamethoxypyridazine in experimental infections caused by Streptococcus pyogenes, Diplococcus pneumoniae, and Streptoc

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

A 1:2-dihydro-s-triazine with marked activity against certain pathogenic bacteria and synergistic with a sulphonamide in experimental bacterial infections.

References

A Metabolite of ‘Paludrine’ with High Antimalarial Activity

'Paludrine' is transformed in the animal body into a more active compound with high antimalarial activity, indicating a unique mode of action compared to other antimalarials.

Citations

Folate antagonists. 7. Antimalarial, antibacterial, and antimetabolite effects of 2,4‐Diamino‐6‐(benzyl and pyridylmethyl)‐5,6,7,8‐tetrahydropyrido[4,3‐d] pyrimidines

2,4-diamino-6-(benzyl and pyridylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines show potent antimalarial and antibacterial effects, with potential applications in malaria treatment and antibiotic resistance

1‐Aryl‐4,6‐diamino‐1,2‐dihydro‐s‐triazines. Contrasting effects on intestinal helminths, bacteria, and dihydrofolic reductase

Potent anthelmintic activity among dihydro-triazines is not solely dependent on the bulky-substituent hypothesis, and cannot reliably be predicted on this basis.

KINETICS AND MECHANISM OF ISOMERIZATION AND HYDROLYSIS OF 4,6-DIAMINO-1-(3,5)-DICHLOROPHENYL-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE IN DILUTE AQUEOUS SOLUTION.

Three routes of inactivation of 4,6-DIAMINO-1-(3,5)-DICHLOROPHENYL-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE in diluted aqueous solution are identified, with specific rates varying