1,2-Oxazoline durch Addition von Trimethylbenzonitriloxid an 2-Hydroxyethylamino-1,4-benzochinone und deren Chinolderivate

doi:10.1007/BF00810865

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1,2-Oxazoline durch Addition von Trimethylbenzonitriloxid an 2-Hydroxyethylamino-1,4-benzochinone und deren Chinolderivate

Published Jun 1, 1990 · M. Schubert-Zsilavecz, D. Gusterhuber, F. Belaj

Monatshefte für Chemie / Chemical Monthly

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Abstract

Addition of trimethylbenzonitril oxide to 2-hydroxyethylamino-1,4-quinones and 3,4-dihydro-4-alkyl-8a-methoxy-2H-1,4-benzoxazin-6(8aH)-ones leads to 7,8,9a,9b-tetrahydro-3aH-1,2-oxazolo[4,5-h]-1,4-benzoxazin-4(6H)-ones. In order to determine constitution and conformation of the addition products an NMR-spectroscopic analysis and an X-ray crystal structure analysis of 6-benzyl-9a-hydroxy-3-mesityl-7,8,9a,9b-tetrahydro-3aH-1,2-oxazolo[4,5-h]-31,4-benzoxazin-4-(6H)-one3a were carried out at room temperature: C_25H_26N_2O_4,M _r=418.49, monoclinic, P2_1/n,a=13.716(6),b=19.993(6),c=15.348(6) Å, β = 98.55(4)°,V=4162(1)Å^3,Z=8,d _x=1.336g/cm^3,R=6.77%,R _w=4.55% (2994 observables, 560 parameters).

Study Snapshot

Trimethylbenzonitril oxide addition to 2-hydroxyethylamino-1,4-quinones and 3,4-dihydro-4-alkyl-8a-methoxy-2H-1,4-benzoxazin-6(8aH)-ones leads to 7,8,9a,

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

1,2-Oxazoline durch Addition von Trimethylbenzonitriloxid an 2-Hydroxyethylamino-1,4-benzochinone und deren Chinolderivate

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