Paper

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.

Published Apr 1, 2009 · Wei Feng, M. Satyanarayana, Y. Tsai

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

12-substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines show potential as novel TOP1-targeting antitumor agents, with potential for clinical development.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.

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