1-(3,4-dimethoxyphenyl)-2-propanol effect on conditioned avoidance response in the rat.

doi:10.1002/JPS.2600591233

Paper

1-(3,4-dimethoxyphenyl)-2-propanol effect on conditioned avoidance response in the rat.

Published Dec 1, 1970 · C. Barfknecht, J. M. Miles, J. L. Leseney

Journal of pharmaceutical sciences

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3

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0

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Abstract

The compound, 1-(3,4-dimethoxyphenyl)-2-propanol, was found to prolong latency times initially in a conditioned avoidance response test in rats. It was found to be a CNS depressant in mice. The structural implications of this action, plus the relationship between 1-(3,4-dimethoxyphenyl)-2-propanol and psychotomimetic amphetamines, are discussed.

Non-RCT

Animal Study

Study Snapshot

1-(3,4-dimethoxyphenyl)-2-propanol prolongs latency times in conditioned avoidance response tests in rats and is a CNS depressant in mice, suggesting a potential relationship with psychotomimetic amphetamines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

1-(3,4-dimethoxyphenyl)-2-propanol effect on conditioned avoidance response in the rat.

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References

NEW DEVELOPMENTS IN METABOLISM OF MESCALINE AND RELATED AMINES *

The metabolism of catechol amines, particularly dopamine, is complex and involves multiple enzymes, with calcium carbimide inhibiting this process.

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Most ring-methoxylated 1-phenyl-2-propanols and 1-phenyl-2-propanones show depressantlike activity, with rabbit liver microsomes readily reducing them, and a linear correlation between partition coefficients and LRA50′s observed for six compounds.

Synthesis of some N-oxygenated products of 3,4-dimethoxyampetamine and its N-alkyl derivatives

This study presents a new method for preparing N,N-dialkylhydroxylamines and a method for analyzing an -unsubstituted nitrone.