1-[4-[(Trimethylsilyl)ethynyl]phenyl]-2,6,7-trioxabicyclo[2.2.2]octanes: a novel type of selective proinsecticide

doi:10.1021/JF00094A040

Paper

1-[4-[(Trimethylsilyl)ethynyl]phenyl]-2,6,7-trioxabicyclo[2.2.2]octanes: a novel type of selective proinsecticide

Published Apr 1, 1990 · C. Palmer, I. H. Smith, Matthew D. V. Moss

Journal of Agricultural and Food Chemistry

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Abstract

4-Alkyl-1-[4-[(trimethylsilyl)ethynyl]phenyl]-2,6,7-trioxabicyclo[2.2.2]octanes are potent insecticides with 24-h housefly topical LD 50 s depending on the 4-substituent, i.e., 0.4-0.7 μg/g for n-propyl, n-butyl, and tert-butyl and 68 μg/g for cyclohexyl. The 4-n-propyl- and 4-n-butyl-1-[4-[(trimethylsilyl)ethynyl]phenyl] compounds have almost the same potency to houseflies as their 1-(4-ethynylphenyl) analogues, suggesting that the trimethylsilyl compounds may be proinsecticides. (...)

Study Snapshot

1-[4-[(Trimethylsilyl)ethynyl]phenyl]-2,6,7-trioxabicyclo[2.2.2]octanes] show potential as a selective proinsecticide for houseflies, with potent insecticidal effects depending on

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

1-[4-[(Trimethylsilyl)ethynyl]phenyl]-2,6,7-trioxabicyclo[2.2.2]octanes: a novel type of selective proinsecticide

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References

Citations

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Pesticides often produce unexpected metabolites with diverse biological activities, challenging our understanding of their toxicological effects and secondary targets.

Alkyne chemistry in crop protection.

Alkyne derivatives play a significant role in crop protection, offering effective herbicidal, fungicidal, insecticidal, and acaricidal properties, as well as intermediates in the preparation of agrochemicals.

Proinsecticides effective against insecticide-resistant peach-potato aphid (Myzus persicae (Sulzer))

Proinsecticides designed to exploit resistance mechanisms in pests can potentially make other classes more toxic, potentially benefiting agriculture.

Novel selective catalytic reduction with tritium: Synthesis of the GABAA receptor radioligand 1‐(4‐ethynylphenyl)‐4‐[2,3‐3H2]propyl‐2,6,7‐trioxabicyclo[2.2.2]octane

Selective catalytic reduction with tritium allows for the synthesis of an improved radioligand for the GABA-gated chloride channel in insects and mammals.

The Use of Synergized Pyrethroids to Control Insect Pests in and Around Domestic, Industrial and Food-handling Premises

Synergized pyrethroids effectively control insect pests in domestic, industrial, and food-handling premises by inhibiting mixed function oxidative mechanisms and increasing insecticide availability.