17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.

doi:10.1016/j.ejphar.2009.06.052

Paper

17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.

Published Sep 1, 2009 · S. Runyon, M. Orr, H. Navarro

European journal of pharmacology

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4

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Abstract

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Non-RCT

Animal Study

Rigorous Journal

Study Snapshot

3-hydroxy-17-nitro-5-androstane and its 3-methyl analog show potent anticonvulsant and anxiolytic activities at GABA A receptors, with nitro serving as a bioisostere for acetyl at the 17-position.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.

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