1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.

doi:10.1021/JM020070B

Paper

1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.

Published Nov 7, 2002 · J. Lien, F. Lee, Li‐Jiau Huang

Journal of medicinal chemistry

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18

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Abstract

Antiapoptotic agents based on 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole (27), and 1-phenyl-3-(5'-hydroxymethyl-2'-furyl)indazole (23) were the most effective inhibitors of sodium nitroprusside-induced vascular smooth muscle cell apoptosis. These three compounds are proposed as potential therapeutic agents for the treatment of sepsis.

In Vitro Study

Study Snapshot

1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole derivatives show potential as effective antiapoptotic agents for treating sepsis and septic shock.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis.

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References

Citations

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Synthesis, Characterization, Antibacterial Activity And Molecular Docking Studies Of Novel Nitrogen Based Indole-2-One Schiff’s Bases

Novel nitrogen-based Indole-2-one Schiff's bases show good antibacterial activity against gram positive and gram negative bacteria, with compounds 4a, 4d, and 4h showing the highest molecular docking score.

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