Paper

1-Isoamyl-3-isobutylxanthine: a remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices.

Published Nov 26, 1979 · F. Smellie, J. Daly, J. N. Wells

Life sciences

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Abstract

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In Vitro Study

Study Snapshot

1-Isoamyl-3-isobutylxanthine is a potent inhibitor of phosphodiesterases involved in regulating cyclic AMP levels in brain tissue, enhancing the effects of norepinephrine, histamine, and adenosine.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

1-Isoamyl-3-isobutylxanthine: a remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices.

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