Potent anticonvulsant activity has been demonstrated for a large number of 1-(naphthylalkyl)-1H-imidazoles containing a variety of functional groups in the alkylene bridge. The presence of a small oxygen function in the bridge, in general, confers a high therapeutic index between anticonvulsant and depressant activity. Clinical expectations are discussed for 1-(2-naphthoylmethyl)imidazole hydrochloride (5), which is undergoing development for testing in humans.

1-(naphthylalkyl)-1H-imidazole derivatives show potent anticonvulsant activity and a high therapeutic index between anticonvulsant and depressant activity, with 1-(2-naphthoylmethyl)imidazole hydrochlor

Paper

1-(Naphthylalkyl)-1H-imidazole derivatives, a new class of anticonvulsant agents.

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