Paper

2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Published Nov 15, 2004 · Dehua Huang, Steve F. Poon, D. Chapman

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

2-(2-(3-(pyridin-3-yloxy)phenyl)-2H-tetrazol-5-yl) pyridine is a highly potent and selective mGlu5 receptor antagonist with good brain penetration and cross-species oral bioavailability.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

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