2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols.

doi:10.1016/j.ejmech.2007.12.017

Paper

2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols.

Published Dec 1, 2008 · Palwinder Singh, Anu Mittal, S. Kaur

European journal of medicinal chemistry

Q2 SJR score

13

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0

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Abstract

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In Vitro Study

Study Snapshot

5-Hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols show significant COX-2 inhibition and selectivity, with the group at C-5 and substituents at the two phenyl rings significantly affecting their activities.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols.

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