2-[3-(7-Chloro-2-methoxy-10-[benzo(b)-1,5-naphthyridinyl]amino)propylamino]ethanol (ICR-372-OH)

doi:10.1107/S0567740875003871

Paper

2-[3-(7-Chloro-2-methoxy-10-[benzo(b)-1,5-naphthyridinyl]amino)propylamino]ethanol (ICR-372-OH)

Published Mar 15, 1975 · J. Glusker, H. L. Carrell, H. Berman

Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry

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Abstract

The crystal structure of 2-[3-(7-chloro-2-methoxy-10-[benzo[b]-l,5-naphthyridinyl]amino)propylamino]ethanol (ICR-372-OH), a weak mutagen for Salmonella, has been studied by X-ray diffraction using three-dimensional data. When the terminal hydroxyl group of the side chain is replaced by a chlorine atom the product (ICR 372) is a very powerful bacterial mutagen. The crystals are triclinic, space ~ o u p PI', with Z = 2 , F.W. 360-84, cell dimensions a=9.473 (1), b=9.280 (1), c= 10-603 (1) ,~, e=99-64 (1), fl= 101.67 (1), y=101-80 (1) °, V=872.1 (2) ~3. The calculated and measured densities are 1.36 and 1.35 g cm -3 respectively. The structural formula is:

Study Snapshot

2-[3-(7-chloro-2-methoxy-10-[benzo(b)-1,5-naphthyridinyl]amino)propylamino]ethanol (ICR-372-OH) is a weak mutagen for Salmonella, with a

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

2-[3-(7-Chloro-2-methoxy-10-[benzo(b)-1,5-naphthyridinyl]amino)propylamino]ethanol (ICR-372-OH)

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References

The X-Ray System of Crystallographic Programs for any Computer Having a Pidgin Fortran Compiler.

The X-Ray System is a machine-independent library of Fortran crystallographic programs for solving crystal structures using diffraction techniques on various operating systems.

Citations

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The structure of Miracil D, a DNA-binding drug.

The crystal structure of DNA-binding drug Miracil D shows a planar thioxanthone ring system with a large degree of conformational mobility.