A series of 2,4-dihydroxy-3-propylacetophenone derivatives containing alkylthiobenzoic or arylacetic acid moiety was prepared. The antileukotrienic activity of the substances was assessed in terms of inhibition of the biosynthesis of LTB 4 and bonding to LTB 4 and LTD 4 receptors. Some of the substances were found to exert a complex antileukotrienic effect in all of the three tests. The compounds also displayed an antiinflammatory effect, as manifested by a significant inhibition of LTD 4 -induced bronchospasm.

2,4-dihydroxyacetophenone derivatives show a complex antileukotrienic effect and antiinflammatory effect, inhibiting LTD4-induced bronchospasm.

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2,4-Dihydroxyacetophenone Derivatives as Antileukotrienics with a Multiple Activity Mechanism

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