Paper
2,6-Bis(trifluoromethyl)phenylboronic Esters as Protective Groups for Diols: A Protection/Deprotection Protocol for Use under Mild Conditions.
Published Sep 18, 2018 · N. Shimada, Sari Urata, K. Fukuhara
Organic letters
Q1 SJR score
10
Citations
0
Influential Citations
Abstract
The application of 2,6-bis(trifluoromethyl)phenyl boronic acid ( o-FXylB(OH)2; o-FXyl = 2,6-(CF3)2C6H3) as a recoverable and reusable protective agent for diols is described. The resulting cyclic boronic esters are water- and air-stable and tolerant to various organic transformations. Moreover, they can be deprotected under mild conditions. This methodology was applied to the synthesis of a highly conjugated enetriyne natural product with anti-angiogenic activities.
Study Snapshot
2,6-bis(trifluoromethyl)phenylboronic esters are a water- and air-stable, reusable protective agent for diols, with potential applications in the synthesis of anti-angiogenic natural products.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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