2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent.

doi:10.1016/j.bmcl.2017.06.025

Paper

2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent.

Published Aug 1, 2017 · Til Bahadur Thapa Magar, T. Kadayat, Hwa-Jong Lee

Bioorganic & medicinal chemistry letters

Q2 SJR score

19

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Abstract

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In Vitro Study

Study Snapshot

2-chlorophenyl-substituted benzofuro[3,2-b]pyridines show excellent topoisomerase II inhibitory activity, with the chlorine substituent playing a crucial role in their strong antiproliferative activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent.

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