2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization.

doi:10.1016/J.BMCL.2007.03.070

Paper

2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization.

Published Jun 1, 2007 · N. Zhang, S. Ayral-Kaloustian, Thai Nguyen

Bioorganic & medicinal chemistry letters

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56

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1

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Abstract

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In Vitro Study

Study Snapshot

This series of 2-cyanoaminopyrimidines shows potential as potent anticancer agents with a unique mechanism of tubulin inhibition, overcoming multidrug resistance due to P-gp.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization.

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References

Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition.

Triazolopyrimidines show high potency and efficacy as anticancer agents, with a unique mechanism of action promoting tubulin polymerization and inhibiting vinca binding to tubulin.

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

HTI-286, a synthetic analogue of hemiasterlin, shows potential as a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance and shows potential in inhibiting human tumor growth.

Targeting microtubules for cancer chemotherapy.

Microtubule-targeting drugs effectively treat cancer by inhibiting cell growth and apoptosis, but their effectiveness is hindered by side effects and drug resistance.

Citations

An overview of the most used synthetic pathways of 1,2,4-triazolo[1,5-a]pyrimidines

The most used synthetic pathways of 1,2,4-triazolo[1,5-a]pyrimidines can help researchers design new drug molecules with expected pharmacological activities.

Synthesis, characterization, DNA interaction, molecular docking, and α‐glucosidase inhibition studies of 3‐(pyrimidin‐2‐ylthio) groups substituted water soluble zinc (II) phthalocyanine

n-MP3 is a strong DNA binding compound with potential antimicrobial and anticancer applications, as well as a very effective -glucosidase inhibitor.

Exploring cyclopropylamine containing cyanopyrimidines as LSD1 inhibitors: Design, synthesis, ADMET, MD analysis and anticancer activity profiling.

Cyclopropylamine-containing cyanopyrimidines show potential as potent LSD1 inhibitors, with compounds VIIb, VIIi, and VIIm showing the most potent anticancer activity against various cancer cell lines.

Recent Progress on Microtubule Degradation Agents.

Microtubule degradation agents (MDgAs) offer a promising approach to overcome drug resistance in microtubule-targeted cancer therapy by degrading the whole target protein.

Synthesis and Spectral, Thermal and Antimicrobial Investigation of Mixed Ligand Metal Complexes of N-Salicylidene Aniline and 1,10-Phenanthroline

The La(III) complex, a mixed ligand metal complex, shows significant antimicrobial activity against Candida albicans compared to other compounds and reference standards.