2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways.

doi:10.1016/j.bcp.2009.10.018

Paper

2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways.

Published Mar 15, 2010 · C. Ting, Y. M. Lee, C. Wong

Biochemical pharmacology

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42

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2

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Abstract

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In Vitro Study

Study Snapshot

2-Methoxyestradiol induces endoreduplication in well-differentiated nasopharyngeal carcinoma cells by inducing oxidative stress and activating MAPK signaling pathways.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways.

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References

In vitro effects of 2‐methoxyestradiol on cell numbers, morphology, cell cycle progression, and apoptosis induction in oesophageal carcinoma cells

2methoxyestradiol significantly reduces cell numbers and induces apoptosis in oesophageal carcinoma cells, suggesting a potential mechanism of apoptosis induction via the extrinsic pathway.

JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125

Constitutive JNK activity promotes proliferation and maintains diploidy in mantle cell lymphoma, but inhibition leads to cell cycle deregulation and endoreduplication, mimicking the tetraploid state seen in some cases.

Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells

Polygonatum cyrtonema lectin (PCL) induces both apoptosis and autophagy in cancer cells through a mitochondria-mediated ROS-p38-p53 pathway, potentially playing a death-promoting role in cancer cells.

Phase I Trial of 2-Methoxyestradiol NanoCrystal Dispersion in Advanced Solid Malignancies

The maximum tolerated dose of 2-Methoxyestradiol NanoCrystal Dispersion is 1,000 mg orally every 6 hours for advanced solid tumors, with treatment generally well-tolerated.

Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain.

MSt-2, a macrosphelide with a thiazole side chain, effectively induces apoptosis in human lymphoma cells through rapid reactive oxygen species generation and mitochondrial dysfunction.

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