(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase.

doi:10.1016/0006-291X(83)90406-0

Paper

DOI: 10.1016/0006-291X(83)90406-0

(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase.

Published Oct 14, 1983 · C. Danzin, P. Casara, N. Claverie

Biochemical and biophysical research communications

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In Vitro Study

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(2R,5R)-6-heptyne-2,5-diamine is a more potent inhibitor of mammalian ornithine decarboxylase than -difluoromethylornithine, making it a potential new treatment for ornith

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.1016/j.abb.2025.110321

Ornithine decarboxylase and its role in cancer.

Ornithine decarboxylase (ODC) is a potential drug target in cancer, as it is overexpressed and regulated by c-Myc, offering a promising therapeutic opportunity.

2025·0citations·J. Filisola-Villaseñor et al.·Archives of biochemistry and biophysics

Archives of biochemistry and biophysics

DOI: 10.3389/fimmu.2022.912279

The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

Targeting polyamine metabolism may offer a new avenue for cancer immunotherapy by altering immune responses and promoting tumor development and progression.

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Polyamine metabolism and cancer: treatments, challenges and opportunities

Targeting polyamine metabolism as an anticancer strategy shows promise, with potential combination therapies and promising clinical trials for both therapy and prevention.

2018·513citations·R. Casero et al.·Nature Reviews Cancer

Nature Reviews Cancer

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Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

Targeting polyamine metabolism and function in cancer and hyperproliferative diseases offers potential for therapeutic intervention and drug development.

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Nature Reviews Drug Discovery

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An appraisal of the developmental importance of polyamine changes in early Xenopus embryos.

In early Xenopus embryos, maintaining a certain ratio of spermidine to putrescine is crucial for normal development.

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