2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.

doi:10.1016/j.bmc.2013.06.038

Paper

2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.

Published Sep 1, 2013 · P. Kowalczyk, K. Sałat, G. Höfner

Bioorganic & medicinal chemistry

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14

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Abstract

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In Vitro Study

Study Snapshot

2-Substituted 4-hydroxybutanamides show potential as inhibitors of -aminobutyric acid transporters mGAT1-mGAT4, with potential antinociceptive and motor coordination effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.

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