2-Substituted 4-(Trifluoromethyl)phenols by Directed ortho-Lithiation

doi:10.1055/S-2001-18440

Paper

2-Substituted 4-(Trifluoromethyl)phenols by Directed ortho-Lithiation

Published 2001 · H. Geneste, B. Schafer

Synthesis

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Abstract

Synthesis 2001, No. 15, 12 11 2001. Article Identifier: 1437-210X,E;2001,0,15,2259,2262,ftx,en;T05401SS.pdf. © Georg Thieme Verlag Stuttgart · New York ISSN 0039-7881 Abstract: A broad variety of 2-substituted 4-(trifluoromethyl)phenols can be prepared in a large scale by o-lithiation and reaction with electrophiles in good to excellent yields. The key for the selectivity is the superior ortho-directing effect of the THP-protected hydroxy group (OTHP) as compared to the CF3-group.

Study Snapshot

Directed ortho-lithiation allows for the efficient preparation of various 2-substituted 4-(trifluoromethyl)phenols in good to excellent yields, with the key being the superior ortho-directing effect of the THP-protected hydroxy group compared to the CF3-group.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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2-Substituted 4-(Trifluoromethyl)phenols by Directed ortho-Lithiation

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