Paper
2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp(3))-H Functionalization of Trifluoroacetimidoyl Chlorides.
Published Apr 7, 2016 · J. Pedroni, N. Cramer
Organic letters
Q1 SJR score
28
Citations
1
Influential Citations
Abstract
Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp(3))-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from anilines. The cyclization operates with catalyst loadings as low as 1 mol % and accommodates a variety of substituents.
Study Snapshot
Pd(0)-catalyzed C(sp(3))-H functionalization enables access to stable 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides, offering potential for drug discovery with low catalyst loadings.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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