2-[[tris(hydroxymethyl)methyl]aminomethylene]cyclohexa-3,5-dien-1(2H)-one and its 6-hydroxy and 6-methoxy derivatives.

doi:10.1107/S0108270103020997

Paper

2-[[tris(hydroxymethyl)methyl]aminomethylene]cyclohexa-3,5-dien-1(2H)-one and its 6-hydroxy and 6-methoxy derivatives.

Published Nov 15, 2003 · M. Odabaşoǧlu, Ç. Albayrak, O. Büyükgüngör

Acta crystallographica. Section C, Crystal structure communications

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Abstract

The title compounds, 2-[[tris(hydroxymethyl)methyl]aminomethylene]cyclohexa-3,5-dien-1(2H)-one, C(11)H(15)NO(4), (I), 6-hydroxy-2-[[tris(hydroxymethyl)methyl]aminomethylene]cyclohexa-3,5-dien-1(2H)-one, C(11)H(15)NO(5), (II), and 6-methoxy-2-[[tris(hydroxymethyl)methyl]aminomethylene]cyclohexa-3,5-dien-1(2H)-one, C(12)H(17)NO(5), (III), adopt the keto-amine tautomeric form, with the formal hydroxy H atom located on the N atom, and the NH group and oxo O atom display a strong intramolecular N-H.O hydrogen bond. The N-H...O hydrogen-bonded rings are almost planar and coupled with the cyclohexadiene rings. The carbonyl O atoms accept two other H atoms from the alcohol groups of adjacent molecules in (I), and one from the alcohol and one from the phenol group in (II), but from only one alcohol H atom in (III).

Study Snapshot

The keto-amine tautomeric compounds 2-[[tris(hydroxymethyl)methyl]aminomethylene]cyclohexa-3,5-dien-1(2H)-one and its 6-hydroxy and 6-methoxy derivatives exhibit strong intramolecular hydrogen bonds, with the carbonyl O atom

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

2-[[tris(hydroxymethyl)methyl]aminomethylene]cyclohexa-3,5-dien-1(2H)-one and its 6-hydroxy and 6-methoxy derivatives.

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