Paper
3‐Amino‐ and 5‐Aminopyrazoles with Anticonvulsant Activity
Published Jun 1, 1999 · H. Lankau, M. Menzer, A. Rostock
Archiv der Pharmazie
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Abstract
New 3‐amino‐ and 5‐aminopyrazoles were synthesised. 3‐Aminopyrazoles exert a strong anticonvulsant effect. 4‐Chlorophenyl‐3‐( morpholin‐4‐yl)‐1H‐pyrazole 2 distinctively blocks sodium channels and is strongly effective in the Maximal Electroshock Seizure (MES) test.
Study Snapshot
3amino and 5aminopyrazoles show strong anticonvulsant effects, with 4Chlorophenyl-3(morpholin-4-yl)-1H-pyrazole 2 effectively blocking sodium channels in the Maximal Electroshock Seizure (MES) test.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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