3,4-Bis-O-propargyl-1,2:5,6-di-O-isopropylidene-d-mannitol: a study of multiple weak hydrogen bonds in the solid state

doi:10.1107/S205322962200897X

Paper

3,4-Bis-O-propargyl-1,2:5,6-di-O-isopropylidene-d-mannitol: a study of multiple weak hydrogen bonds in the solid state

Published Oct 11, 2022 · A. I. Mohammed, M. Bhadbhade, R. Read

Acta Crystallographica. Section C, Structural Chemistry

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Abstract

Primary weak hydrogen bonds in each of three independent molecules in 3,4-bis-O-propargyl-1,2:5,6-di-O-isopropylidene-d-mannitol are elucidated by single-crystal X-ray diffraction and their importance in molecular conformation and crystal packing determined. Parallel searches of the Cambridge Structural Database using motifs based on donor and acceptor propargyl D—H⋯A contacts reveal distance and angle dependencies that are especially sensitive to acceptor type, so, together, these findings will be beneficial in applications for the molecule and its congeners as anion binders and precursors for the synthesis of macrocycles.

Study Snapshot

Weak hydrogen bonds in 3,4-bis-O-propargyl-1,2:5,6-di-O-isopropylidene-d-mannitol play a crucial role in molecular conformation and crystal packing, impacting its applications as anion binders and precursors

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

3,4-Bis-O-propargyl-1,2:5,6-di-O-isopropylidene-d-mannitol: a study of multiple weak hydrogen bonds in the solid state

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