3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists.

doi:10.1016/J.BMCL.2006.12.093

Paper

3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists.

Published Jun 15, 2007 · S. Zhao, J. Berger, R. D. Clark

Bioorganic & medicinal chemistry letters

Q2 SJR score

37

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1

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Abstract

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Study Snapshot

Novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives show subnanomolar affinities for 5-HT6 receptors and good brain penetration in rats, with potential for use in treating various psychiatric disorders.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists.

References

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