[Effect of 3-aminobenzamide on DNA replication and DNA repair synthesis in S180 cells].

Paper

[Effect of 3-aminobenzamide on DNA replication and DNA repair synthesis in S180 cells].

Published Jul 1, 1986 · DOI · G. Chen, Q. Pan

Zhongguo yao li xue bao = Acta pharmacologica Sinica

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Abstract

To elucidate the mechanism by which 3-aminobenzamide (3-AB) enhanced the antitumor effect of bleomycin A5 (BLMA5) on S180. We studied the effects of 3-AB on the DNA-replication synthesis and DNA-repair synthesis both in untreated and BLMA5-treated S180 cells. 3-AB 2 mM stimulated DNA-repair synthesis after the cells were exposed to BLMA5 for 30 min, but 5 and10 mM inhibited DNA-replication synthesis and enhanced the inhibition of DNA-replication synthesis by BLMA5 respectively. 3-AB affected DNA-repair synthesis more rapidly than DNA-replication. The results indicate that more than one mechanism are involved in the above-mentioned process.

In Vitro Study

Study Snapshot

3-aminobenzamide enhances the antitumor effect of bleomycin A5 on S180 cells by stimulating DNA-repair synthesis and inhibiting DNA-replication synthesis, with multiple mechanisms involved.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

[Effect of 3-aminobenzamide on DNA replication and DNA repair synthesis in S180 cells].

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