Paper

3-Deazaadenosine, an S-adenosylhomocysteine hydrolase inhibitor, attenuates lipopolysaccharide-induced inflammatory responses via inhibition of AP-1 and NF-κB signaling.

Published Oct 6, 2020 · DOI · Woo Seok Yang, Ji Hye Kim, Deok Jeong

Biochemical pharmacology

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Abstract

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In Vitro Study

Study Snapshot

3-Deazaadenosine inhibits inflammatory responses by directly blocking MEK1/2 and IKK/ or indirectly through SAHH, resulting in anti-inflammatory activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

3-Deazaadenosine, an S-adenosylhomocysteine hydrolase inhibitor, attenuates lipopolysaccharide-induced inflammatory responses via inhibition of AP-1 and NF-κB signaling.

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