3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights.

doi:10.1016/j.ejmech.2019.111768

Paper

DOI: 10.1016/j.ejmech.2019.111768

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights.

Published Dec 15, 2019 · Mahmoud F. Abo-Ashour, Wagdy M. Eldehna, A. Nocentini

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

3-Hydrazinoisatin-based benzenesulfonamides show potent inhibitory activities against tumor-associated human carbonic anhydrase isoforms and show promising anti-proliferative activity against various cancer cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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