Paper
3-isothiocyanato oxindoles serving as powerful and versatile precursors to structurally diverse dispirocyclic thiopyrrolidineoxindoles through a cascade Michael/cyclization process with amino-thiocarbamate catalysts.
Published Apr 26, 2013 · Wenyong Han, Shi-Wu Li, Zhijun Wu
Chemistry
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Abstract
Cascading catalysis: 3-Isothiocyanato oxindoles act as powerful and versatile precursors for a range of structurally diverse dispirocyclic thiopyrrolidineoxindoles containing two spiro-quaternary and three contiguous stereogenic centers in quantitative yields with excellent disatereo- and enantioselectivities by only using 1 mol % amino-thiocarbamate catalyst.
Highly CitedStudy Snapshot
3-isothiocyanato oxindoles serve as powerful and versatile precursors for diverse dispirocyclic thiopyrrolidineoxindoles with excellent disatereo- and enantioselectivities using only 1 mol% amino-thiocarbamate catalyst.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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