4-(2',4'-DIFLUOROBIPHENYL-4-YL)-2-METHYL-4-OXOBUTANOIC ACID AND ITS DERIVATIVES

doi:10.1135/CCCC19942705

Paper

4-(2',4'-DIFLUOROBIPHENYL-4-YL)-2-METHYL-4-OXOBUTANOIC ACID AND ITS DERIVATIVES

Published 1994 · M. Kuchař, M. Poppová, H. Zunova

Collection of Czechoslovak Chemical Communications

UNKNOWN SJR score

6

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Friedel Crafts reaction of itaconic anhydride ( III ) with 2,4-difluorobiphenyl ( II ) afforded unsaturated acid IV which was hydrogenated to give 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid ( I ). A series of functional derivatives and salts of the acid I has been prepared. The antiinflammatory effect of these compounds was compared with that of acid I using selected experimental inflammation models. The analgesic activity in the intraperitoneal irritation test was also evaluated. In the case of ( R )-(+)-1-phenylethylamide Vf the ratio of the diastereoisomers was determined by HPLC.

In Vitro Study

Study Snapshot

The derivatives and salts of 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid show promising antiinflammatory and analgesic properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

4-(2',4'-DIFLUOROBIPHENYL-4-YL)-2-METHYL-4-OXOBUTANOIC ACID AND ITS DERIVATIVES

References

Citations

Dissecting CYP1A2 Activation by Arylalkanoic Acid Prodrugs toward the Development of Anti-Inflammatory Agents

Arylalkanoic acid prodrugs show potential for developing new potent and safe anti-inflammatory agents, with their activation by CYP1A2 dependent on their molecular structures.

History of Quantitative Structure–Activity Relationships

The QSAR paradigm has evolved over the past 50 years, with molecular descriptors playing a crucial role in high-throughput screening and database development.

Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin

Transkarbam 12 (T12) is a promising biodegradable permeation enhancer for a wide range of drugs, with its activity being pH-dependent and warranting further investigation.

Structural study of flobufen II. An unexpected role of packing effects on the dihedral angle of phenyl rings in crystal structures of 2,4-difluorobiphenyls

The crystal structure of (R)-(+)-flobufen reveals an unexpected coplanar arrangement of the 2,4-difluorobiphenyl group due to the three-dimensional hydrogen-bond network of molecular packing.

Separation of the stereoisomers of the main metabolite of a non-steroidal anti-inflammatory drug, flobufen, by chiral high-performance liquid chromatography.

The chiral chromatographic system optimized in this study effectively separates the (++)() racemate of flobufen's main metabolite, enabling a biochemical study of its stereoisomeric metabolism.