4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.

doi:10.1016/j.bmcl.2009.01.063

Paper

DOI: 10.1016/j.bmcl.2009.01.063

4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.

Published Mar 1, 2009 · L. Mitchell, Z. Wang, L. Hu

Bioorganic & medicinal chemistry letters

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Thioether-substituted benzonitriles show potential as topical androgen receptor antagonists for sebum suppression in a Golden Syrian hamster ear model.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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