4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

doi:10.1016/J.BMCL.2007.02.066

Paper

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

Published May 15, 2007 · J. L. Duffy, Brian A. Kirk, Liping Wang

Bioorganic & medicinal chemistry letters

Q2 SJR score

18

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Abstract

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In Vitro Study

Study Snapshot

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives are potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV, with cyclohexylalanine derivatives showing improved PK exposure and efficacy

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.

References

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