Paper
4-Aminoquinoline-1,3,5-triazine: Design, synthesis, in vitro antimalarial activity and docking studies
Published Aug 12, 2013 · H. Bhat, U. Singh, P. Gahtori
New Journal of Chemistry
Q2 SJR score
48
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0
Influential Citations
Abstract
A series of hybrid 4-aminoquinoline 1,3,5-triazine derivatives was synthesized and their chemical structure were confirmed by 1H-NMR, 13C-NMR, FT-IR and mass spectrometric analyses. In vitro antimalarial activity of these compounds was evaluated against chloroquine-sensitive (3D-7) and chloroquine resistant (RKL-2) strains of P. falciparum. Results showed that all compounds had considerable antimalarial activity against both the strains and further docking studies were performed on both wild type (1J3I.pdb) and quadruple mutant (N51I, C59R, S108 N, I164L, 3QG2.pdb) pf-DHFR-TS to quantify the structural parameter necessary for the activity.
In Vitro StudyStudy Snapshot
4-aminoquinoline 1,3,5-triazine derivatives show considerable antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum, with potential for further development into new antimalarial drugs.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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