4-hydroxy-2-quinolones. 202*. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides

doi:10.1007/s10593-012-0992-4

Paper

4-hydroxy-2-quinolones. 202*. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides

Published Jun 3, 2012 · I. Ukrainets, O. Bevz, E. Mospanova

Chemistry of Heterocyclic Compounds

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11

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Abstract

In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented.

Study Snapshot

4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides show potential as analgesics due to their synthesis method and conventional bromination method.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

4-hydroxy-2-quinolones. 202*. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides

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4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids show potential as analgesic compounds due to their acidic properties and NMR spectra.

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Citations

Comprehensive chemical profiling with UHPLC-MS, in-vitro, in-silico, and in-vivo antidiabetic potential of Typha domingensis Pers; A novel source of bioactive compounds

Typha domingensis Pers. possesses a variety of bioactive compounds and shows notable potential in regulating diabetes and improving renal and liver function.

BiCl3-catalyzed green synthesis of 4-hydroxy-2-quinolone analogues under microwave irradiation

BiCl3-catalyzed green synthesis of 4-hydroxy-2-quinolone analogues under microwave irradiation is a safer, eco-friendly, and effective method for producing new compounds.

4-Hydroxy-2-quinolones: syntheses, reactions and fused heterocycles

Recent synthetic approaches and applications of 4-hydroxy-2-quinolones in drug research and development reveal unique biological activities.

Molecular Conformations and Biological Activity of N-Hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides

N-hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-26,1-benzothiazine-3-carboxamides show significant analgesic and anti-inflammatory properties, with N-Thiophen-2-ylmethyl- and N

Using Bioisosteric Replacements to Enhance the Analgesic Properties of 4-Hydroxy-6,7-Dimethoxy-2-oxo-1,2-Dihydroquinoline-3-Carboxamides

Bioisosteric replacement of the benzyl phenyl ring in 4-Hydroxy-6,7-Dimethoxy-2-oxo-1,2-Dihydroquinoline-3-Carboxamides significantly increases analgesic activity in the 3-Py derivative.