4-hydroxy-2-quinolones. 201*. Synthesis, structure, and diuretic activity of hydroxy- and alkoxy- anilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro- 1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

doi:10.1007/S10593-011-0882-1

Paper

4-hydroxy-2-quinolones. 201*. Synthesis, structure, and diuretic activity of hydroxy- and alkoxy- anilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro- 1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

Published Dec 14, 2011 · I. Ukrainets, N. Y. Golik, A. L. Shemchuk

Chemistry of Heterocyclic Compounds

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Abstract

Hydroxy- and alkoxyanilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids have been synthesized as potential diuretic agents. Features of their purification, their steric structure, and biological activity are discussed.

Study Snapshot

Hydroxy- and alkoxyanilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid show potential diuretic activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

4-hydroxy-2-quinolones. 201*. Synthesis, structure, and diuretic activity of hydroxy- and alkoxy- anilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro- 1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

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References

4-hydroxy-2-quinolones. 200*. Bromination of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyridinylmethylene hydrazides

Bromination of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyridinylmethylene-hydrazides leads to halocyclization of 1-N-allyl derivatives and unexpected bromination of 1-N-hexyl-

4-hydroxy-2-quinolones. 197*. The search for novel diuretics amongst halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline-5-carboxylic acid anilides

Halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline-5-carboxylic acid anilides show potential as novel diuretics with promising 1H NMR spectra and di

4-hydroxy-2-quinolones. 179*. Synthesis, structure, and anti-inflammatory activity of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid and its derivatives

4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-ylacetic acid and its derivatives show promising anti-inflammatory properties.

A short history of SHELX.

SHELX has evolved from SHELX-76 to the present day, incorporating useful innovations and enduring popularity in various molecular applications.

Citations

Polymorphic modifications of a 1H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide possessing strong diuretic properties.

The diuretic compound 1H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide has two polymorphic forms, triclinic and monoclinic, with different crystal packing and potential applications in hypertension treatment.

The Study of the Structure-Diuretic Activity Relationship in a Series of New N-(Arylalkyl)-6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo-[3,2,1-ij]quinoline-5-carboxamides.

New N-(arylalkyl)-6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxamides show promising diuretic effects, potentially surpassing hydrochlorothiazide and