The 4-methoxy-2,6-dimethylbenzenesulphonyl (Mds) group for the protectiono of the guanidino function, which is readily removed with trifluoroacetic acid–thioanisole but is resistant to hydrogenolysis or treatment with dilute hydrogen chloride, can be used in the solution synthesis of arginine-containing peptides; this protecting group was effectively used in the synthesis of substance P and two LH–RH analogues.

The 4-methoxy-2,6-dimethylbenzenesulphonyl (Mds) group is a promising protecting group for arginine-containing peptides, effectively used in the synthesis of substance P and LH-RH analogues.

Paper

4-Methoxy-2,6-dimethylbenzenesulphonyl (Mds): a new protecting group of the guanidino function in peptide synthesis

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