4-Oxoazetidine-2-carbaldehydes as useful building blocks in stereocontrolled synthesis

doi:10.1039/B007908L

Paper

4-Oxoazetidine-2-carbaldehydes as useful building blocks in stereocontrolled synthesis

Published Aug 13, 2002 · B. Alcaide, P. Almendros

Chemical Society Reviews

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136

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Abstract

4-Oxoazetidine-2-carbaldehydes or 4-formyl-β-lactams can be considered both as protected α-amino aldehydes and masked β-amino acids. These bifunctional compounds exhibit a valuable dual reactivity, which has been utilized in a broad range of synthetic applications. The present review is a survey of the recent salient synthetic achievements exploiting 4-oxoazetidine-2-carbaldehydes, with particular emphasis on diastereoselective processes. The usefulness of these substrates for the preparation of substances of biological interest, including α-amino acids, β-amino acids, amino sugars, polycyclic-β-lactams, alkaloids, and complex natural products is presented.

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4-Oxoazetidine-2-carbaldehydes are useful building blocks for stereocontrolled synthesis of biologically important substances, including -amino acids, -amino acids, amino sugars, polycyclic--lactams, alkaloids, and complex natural

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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4-Oxoazetidine-2-carbaldehydes as useful building blocks in stereocontrolled synthesis

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Citations

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