4-Phenyl-2-(1-piperazinyl)quinolines with potent antidepressant activity.

doi:10.1248/CPB.28.2618

Paper

4-Phenyl-2-(1-piperazinyl)quinolines with potent antidepressant activity.

Published Sep 25, 1980 · K. Hino, K. Furukawa, Y. Nagai

Chemical & pharmaceutical bulletin

Q3 SJR score

36

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0

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Abstract

A series of 2-amino-4-phenylquinolines was synthesized and the effects of these compounds on the central nervous system were evaluated pharmacologically in mice. Among these compounds, many 2-(substituted piperazinyl) derivatives exhibited a potent antagonism to hypothermia and catalepsy induced by reserpine, as well as some inhibitory effect on locomotor activity. Some compounds were found to possess activity to inhibit tremorine-induced tremor.

Non-RCT

Animal Study

Study Snapshot

2-amino-4-phenylquinolines show potent antidepressant activity, antagonism to hypothermia and catalepsy induced by reserpine, and inhibitory effects on locomotor activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

4-Phenyl-2-(1-piperazinyl)quinolines with potent antidepressant activity.

References

Citations

Selenium‐Mediated Cyclization Reaction of 2‐Vinylanilines with/without Isonitriles: Efficient Synthesis of 2‐Aminoquinoline/ 3‐Aryl‐1 H ‐indole Derivatives

Selenium-mediated cyclization of 2'-vinylanilines with/without isonitriles efficiently synthesizes 2'-aminoquinoline and 3'-aryl-1H-indole derivatives in good to excellent yields using low toxicity Se as a catalyst.

Ultrasound-accelerated green synthesis of new quinolin-2-thione derivatives and antimicrobial evaluation against Escherichia coli and Staphylococcus aureus

Ultrasound-accelerated green synthesis of quinolinthione derivatives demonstrates high conversion, cleaner procedure, and short reaction times, with derivative 6b showing the highest antibacterial activity against Staphylococcus aureus and Escherichia coli.

A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones

This eco-friendly microwave-mediated method efficiently synthesizes novel antimicrobial substituted quinoline-2-thiones, with compound 6j showing the greatest potency against Klebsiella pneumonia and Staphylococcus aureus.

Lactamization of sp2 C–H bonds with CO2 under transition-metal-free and redox-neutral conditions: a computational mechanistic study

The lactamization of aniline sp2 C-H bonds with CO2 to 2-quinoline under transition-metal-free and redox-neutral conditions involves three stages, with the base reducing energy barriers and promoting the reaction.

Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones.

Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 is a powerful method for synthesizing quinoline-2-thiones, offering advantages like short synthesis steps and easily available starting materials.