4-Substituted 1-(2-methylphenyl)thieno[2,3-c]-1,5-naphthyridines as possible reversible inhibitors of gastric H+,K+-ATPase

doi:10.1016/0223-5234(96)89168-9

Paper

4-Substituted 1-(2-methylphenyl)thieno[2,3-c]-1,5-naphthyridines as possible reversible inhibitors of gastric H+,K+-ATPase

Published 1996 · P. Björk, A. Hörnfeldt, S. Gronowitz

European Journal of Medicinal Chemistry

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Abstract

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In Vitro Study

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4-Substituted 1-(2-methylphenyl)thieno[2,3-c]-1,5-naphthyridines show potential as reversible inhibitors of gastric H+,K+-ATPase, but their inhibitory potency in vitro is not high

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

4-Substituted 1-(2-methylphenyl)thieno[2,3-c]-1,5-naphthyridines as possible reversible inhibitors of gastric H+,K+-ATPase

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References

Improved syntheses of thieno[2,3-b]- and [3,2-b]-fused naphthyridines

This improved method allows for the synthesis of eight isomeric thieno[2,3-b]- and [3,2-b]-fused naphthyridines with improved yields and a lower cost.

On the bromination of thieno[c]-fused 1,5-naphthyridines and their isomeric N-oxides using dibromoisocyanuric acid in fuming sulfuric acid

Thieno[c]-fused 1,5-naphthyridines and their isomeric N-oxides can be brominated at room temperature using dibromoisocyanuric acid in fuming sulfuric acid, with good to moderate yields at the position in the thioph

The effect of some additives on the Stille Pd0-catalyzed cross-coupling reaction

Adding cupric oxide to the Stille reaction leads to faster reaction and higher yields, especially for thieno[3,2-h]-1,6-naphthyridine formation.

Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent.

13a (SK&F 96356) is a potent inhibitor of gastric acid secretion and a useful fluorescent probe for studying the structure and function of the gastric (H+/K+)-ATPase.

Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogues of 4-(arylamino)quinolines.

1-arylpyrrolo[3,2-c]quinolines 6 and their derivatives show potent inhibitory effects on gastric (H+/K+)-ATPase, with some showing potent inhibition of pentagastrin-stimulated acid secretion in rats.

Citations

Recent advances in proton pump inhibitors and management of acid-peptic disorders.

Proton pump inhibitors (PPIs) are widely used for treating gastric acid diseases, with recent advances in their molecular aspects and biological evaluation methods.

Chapter 5.1 Five-membered ring systems: Thiophenes & Se, Te analogs

Thiophenes play a crucial role in commercial applications and research, with potential for new catalysts in hydrodesulfurization processes and ring-annelated derivatives.