The transformations of 5-methoxy, 6-methoxy and 7-methoxy-a-tetralones are described. Studies on the synthesis of diterpenes veadeiroic acid 12, triptolide 18, sesquiterpenes biflorin 25, mansonone F 26, cacalol 39 and a potential intermediate for 11-deoxydaunomycinone 59 from 5-methoxy-a-tetralone 1 are discussed. Several intermediates for diterpenoid compounds and a total synthesis of phytoalexin orchinol 53 from 6-methoxy-a-tetralone 2 have been accomplished. 7-Methoxy-a-tetralone 3 has proved to be a suitable starting material for a simple and short synthesis of cadinene dihydrochloride 45.

5-Methoxy-a-tetralones can be used for the synthesis of diterpenes, sesquiterpenes, and other natural products, with potential applications in pharmaceutical and biotechnology industries.

Paper

Use of 5‐Methoxy, 6‐Methoxy and 7‐Methoxy‐α‐tetralones in the Synthesis of Diterpenes, Sesquiterpenes and Other Natural Products

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