5-Amino-N-(2,2-dialkoxyethyl)pyrazole-4-carboxamides in the synthesis of 7-sulfanyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepin-4-ones

doi:10.1134/S107042801405011X

Paper

5-Amino-N-(2,2-dialkoxyethyl)pyrazole-4-carboxamides in the synthesis of 7-sulfanyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepin-4-ones

Published Jun 14, 2014 · A. V. Bol’but, S. Kemskii, M. Vovk

Russian Journal of Organic Chemistry

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Abstract

Abstract5-Amino-N-(2,2-dialkoxyethyl)pyrazole-4-carboxamides obtained by hydrolytic cleavage of 5-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-4-ones or by condensation of 3-(dimethylamino)-N-(2,2-dimethoxyethyl)-2-cyanoacrylamides with alkylhydrazines in formic acid react with benzylthiol or thiophenols to afford 7-benzyl(aryl)sulfanyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepin-4-ones.

Study Snapshot

5-Amino-N-(2,2-dialkoxyethyl)pyrazole-4-carboxamides can be used to synthesize 7-benzyl(aryl)sulfanyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

5-Amino-N-(2,2-dialkoxyethyl)pyrazole-4-carboxamides in the synthesis of 7-sulfanyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepin-4-ones

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References

Citations

Metal-free internal nucleophile-triggered domino route for synthesis of fused quinoxaline [1,4]-diazepine hybrids and the evaluation of their DNA binding properties.

Our metal-free synthesis of fused quinoxaline [1,4]-diazepine hybrids allows for diverse structural designs and DNA binding properties, potentially offering new methods for antiproliferative and cancer cell targeting.

Novel family of fused tricyclic [1,4]diazepines: Design, synthesis, crystal structures and molecular docking studies

A new one-pot strategy for synthesis of imidazo[1,4]diazepines has been developed, with potential therapeutic applications in treating anxiety and depression.

Interaction of 1,5,6,8-tetrahydropyrazolo[3,4-е][1,4]diazepine-4,7-diones with some electrophilic reagents

Acetic anhydride and p-toluensulfonyl isocyanate acylate 1,5,6,8-tetrahydropyrazolo[3,4-e][1,4]diazepine-4,7-diones, leading to the formation of

Electrophilic cyclization of N-allyl(propargyl)-5-amino-1H-pyrazole-4-carboxamides. Synthesis of 4-[(dihydro)oxazol-2-yl]-1H-pyrazol-5-amines

This study demonstrates that electrophilic cyclization of N-allyl(propargyl)-5-amino-1H-pyrazole-4-carboxamides can lead to the synthesis of 4-[(dihydro)oxazol-2-yl]-1H-pyrazol-5

Synthesis of 4-hydrazinyl-1,6-dihydropyrazolo[3,4-e][1,4]diazepines and their hydrolytic recyclization to 5-amino-4-(1,2,4-triazin-3-yl)-1H-pyrazoles

4-hydrazinyl-1,6-dihydropyrazolo[3,4-e][1,4]diazepines were synthesized and hydrolytically recyclized to 5-amino-4-(1,2,4-triazin-3-yl)-1H-pyr