Paper

5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

Published Aug 12, 2002 · J. Christman

Oncogene

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Abstract

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Study Snapshot

5-Azacytidine and 5-aza-2′-deoxycytidine inhibit DNA methylation, potentially enabling less toxic cancer therapies by reactivating critical regulatory genes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

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