5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes.

doi:10.1016/j.bioorg.2017.03.007

Paper

5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes.

Published Jun 1, 2017 · Tanzila Arshad, K. Khan, Najma Rasool

Bioorganic chemistry

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73

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Abstract

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Study Snapshot

5-Bromo-2-aryl benzimidazole derivatives show potential as potent and non-cytotoxic dual inhibitors of -glucosidase and urease enzymes for diabetes and peptic ulcer treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α-glucosidase and urease enzymes.

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References

Coumarin sulfonates: As potential leads for ROS inhibition.

Coumarin sulfonates show potential as anti-inflammatory agents due to their suppressive effect on reactive oxygen species production compared to ibuprofen.

Syntheses of new 3-thiazolyl coumarin derivatives, in vitro α-glucosidase inhibitory activity, and molecular modeling studies.

New 3-thiazolyl coumarin derivatives show strong inhibitory activity against -glucosidase, with nontoxic properties, and electron-rich centers at one end showing strong inhibitory activity.

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives.

Newly synthesized thiazole derivatives show potent -glucosidase inhibitory activities, with most showing potent inhibitory potential and being mostly non-toxic.

Dihydropyrimidones: As novel class of β-glucuronidase inhibitors.

Dihydropyrimidones show potential as a novel class of -glucuronidase inhibitors, with compounds 8 and 37 showing more potent inhibitory activity than standard d-saccharic acid 1,4-lactone.

Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors

Five-bromo-2-aryl benzimidazoles show excellent to moderate -glucosidase inhibitory activity, with compound 17 being five-fold more active than the standard drug acarbose.

Citations