Paper
5-Fluoro-2'-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation.
Published Oct 1, 1981 · N. Tommerup, H. Poulsen, K. Brøndum‐Nielsen
Journal of Medical Genetics
91
Citations
0
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Abstract
5-Fluoro-2'-deoxyuridine (FUdR) was found to be highly effective in inducing the heritable fragile site on Xq28 associated with mental retardation. Lymphocytes from two affected males manifested the fragile site in 30 to 40% of the mitoses when grown in the presence of FUdR. This observation suggests that depletion of the dTMP pool via thymidylate synthetase inhibition is responsible for the expression of the heritable fragile site on Xq28.
In Vitro Study
Highly Cited5-Fluoro-2'-deoxyuridine effectively inducing the fragile site on Xq28 associated with mental retardation, suggesting depletion of the dTMP pool through thymidylate synthetase inhibition.
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