Paper
5'-nitro-indirubinoxime induces G2/M cell cycle arrest and apoptosis in human KB oral carcinoma cells.
Published Feb 8, 2009 · Soo-A Kim, Si-Wouk Kim, Sunghoe Chang
Cancer letters
Q1 SJR score
27
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
5′-NIO effectively inhibits oral cancer cell growth by inducing apoptosis and cell cycle arrest in human KB oral carcinoma cells, suggesting potential as a therapeutic modality for oral cancer treatment.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Antitumor Activity of Novel Indirubin Derivatives in Rat Tumor Model
Novel indirubin derivatives effectively inhibit tumor growth by inhibiting cell proliferation and inducing apoptosis in a rat tumor model.
2007·76citations·Soo-A Kim et al.·Clinical Cancer Research
Clinical Cancer Research
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells
Indirubin derivatives E804 and E564 effectively block Stat3 signaling and induce apoptosis in human breast and prostate cancer cells, suggesting their potential antitumor activity.
2005·305citations·Sangkil Nam et al.·Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Cyclin-dependent kinase inhibitor indirubin-3′-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies
Indirubin-3′-oxime selectively inhibits HPV-16 E7-induced abnormal centrosome duplication, suggesting cyclin/CDK2 activity is crucial for abnormal centrosome duplication but not essential for normal centrosome duplication and cell cycle progression.
2004·73citations·S. Duensing et al.·Oncogene
Oncogene
Indirubin-3′-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons
Indirubin-3′-oxime effectively inhibits c-Jun NH2-terminal kinase, preventing neuronal apoptosis in cerebellar granule neurons, independent of its inhibition on CDKs and GSK-3.
2004·50citations·Yuanbin Xie et al.·Neuroscience Letters
Neuroscience Letters
Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine
Indirubin and its derivatives show strong promise for clinical anticancer activity and may be useful in noncancer indications like Alzheimer's disease and diabetes.
2004·190citations·G. Eisenbrand et al.·Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology
Mechanisms of caspase activation.
The initiator caspases activate through proximity-induced dimerization without cleavage, redefining feedback regulation of apoptosis.
2003·1414citations·K. Boatright et al.·Current opinion in cell biology
Current opinion in cell biology
Polo‐like kinase 1 (PLK1) is overexpressed in primary colorectal cancers
Overexpression of PLK1 in primary colorectal cancers is associated with pathogenic, prognostic, and proliferative aspects, suggesting its potential as a new tumor marker for colorectal cancers.
2003·284citations·Takao Takahashi et al.·Cancer Science
Cancer Science
Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1
Orchestrated phosphorylation within the cytoplasmic retention signal triggers rapid import of cyclin B1 during mitotic progression, with phosphorylation of Ser-133 being crucial for rapid nuclear translocation.
2002·135citations·Juping Yuan et al.·Oncogene
Oncogene
Citations
Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins
Indirubin-based small molecules show potential in treating squamous cell carcinoma due to their proapoptotic and antiproliferative activity, targeting common genetic alterations in skin cancers.
2021·15citations·M. Schäfer et al.·Cancers
Cancers
Isatin dimers and their biological activities
Isatin dimers show potential as promising drug candidates with enhanced activity, reduced toxicity, and improved pharmacological, pharmacokinetic, and physicochemical profiles.
2020·41citations·Yazhou Zhang et al.·Archiv der Pharmazie
Archiv der Pharmazie
Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine.
Indirubin exhibits anticancer activity by disrupting microtubule polymerization dynamics, which may be a potential mechanism for its anti-cancer properties.
2018·27citations·L. Mohan et al.·Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Human microdosing and mice xenograft data of AGM-130 applied to estimate efficacious doses in patients
Microdose PK and xenograft PK/PD model can predict efficacious doses of AGM-130 for cancer patients before first-in-human trials.
2017·5citations·W. Park et al.·Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology
Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.
6ha is a potent water-soluble indirubin-based IGF-1R inhibitor, inhibiting tumor cell growth and inducing apoptosis.
2017·36citations·Xinlai Cheng et al.·Journal of medicinal chemistry
Journal of medicinal chemistry