6-Bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites

doi:10.1016/S0960-894X(97)00020-6

Paper

DOI: 10.1016/S0960-894X(97)00020-6

6-Bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites

Published Feb 4, 1997 · H. Viola, M. Marder, C. Wolfman

Bioorganic & Medicinal Chemistry Letters

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Abstract

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Study Snapshot

6-bromo-3′-nitroflavone is a new high affinity benzodiazepine receptor agonist that produces anxiolytic effects in mice at doses of 0.01 to 0.3 mg/kg.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1006/BBRC.1996.0903

6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.

6-Bromoflavone, a high affinity ligand for central benzodiazepine receptors, exhibits clear anxiolytic activity in mice at 0.5 mg/kg i.p.

1996·62citations·M. Marder et al.·Biochemical and biophysical research communications

Biochemical and biophysical research communications

DOI: 10.1016/0960-894X(95)00464-5

6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties

6,3'-dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor, exhibits potent anxiolytic effects in mice at a dose of 1 g/Kg.

1995·35citations·M. Marder et al.·Bioorganic & Medicinal Chemistry Letters

Bioorganic & Medicinal Chemistry Letters

DOI: 10.1055/S-2006-958058

Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.

Apigenin, a component of Matricaria recutita flowers, has anxiolytic and slight sedative effects without being anticonvulsant or myorelaxant.

1995·370citations·H. Viola et al.·Planta medica

Planta medica

DOI: 10.1016/0091-3057(94)90103-1

Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora Coerulea

Chrysin, a natural monoflavonoid from Passiflora Coerulea, possesses anxiolytic effects without inducing sedation and muscle relaxation, suggesting it is a partial agonist of central BDZ receptors.

1994·370citations·C. Wolfman et al.·Pharmacology Biochemistry and Behavior

Pharmacology Biochemistry and Behavior

DOI: 10.1523/JNEUROSCI.12-03-01040.1992

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

The alpha 1 beta 2 gamma 2 receptors are responsible for benzodiazepine I binding, while alpha 2, alpha 3, and alpha 5 contribute to BZ II site subtypes.

1992·1569citations·W. Wisden et al.

Citations

DOI: 10.1155/2015/516878

In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives

Halogenated flavone derivatives show more enzyme inhibitions and antioxidant activities than simple flavones, making them potential candidates for treating various diseases.

2015·15citations·M. Shoaib et al.·Journal of Chemistry

Journal of Chemistry

DOI: 10.1002/CHIN.201504283

Synthesis and Transformation of Halochromones

Halochromones show potential as lead structures in drug development, with various types found in nature, including flavones, isoflavones, 3-methylchromones, and 2-styrylchromones.

2014·12citations·Sara M Tomé et al.·ChemInform

ChemInform

DOI: 10.2147/JEP.S23105

Flavonoids as GABAA receptor ligands: the whole story?

Natural and synthetic flavonoids show selective affinity for GABA type A receptors, offering potential as alternative treatments for mental disorders and tools for studying modulatory sites.

2012·84citations·C. Wasowski et al.·Journal of Experimental Pharmacology

Journal of Experimental Pharmacology

DOI: 10.1255/ejms.1020

Structural Characterization of Nitrated 2′-Hydroxychalcones by Electrospray Ionization Tandem Mass Spectrometry

Small changes in substitution patterns in 2′-hydroxynitrochalcones significantly affect their fragmentation patterns, allowing for the differentiation of specific isomers in electrospray ionization tandem mass spectrometry.

2009·2citations·A. R. Barros et al.·European Journal of Mass Spectrometry

European Journal of Mass Spectrometry

DOI: 10.1016/J.EJPHAR.2005.02.034

6-Methylflavanone, a more efficacious positive allosteric modulator of γ-aminobutyric acid (GABA) action at human recombinant α2β2γ2L than at α1β2γ2L and α1β2 GABAA receptors expressed in Xenopus oocytes

6-methylflavanone is more efficacious as a positive allosteric modulator at 222L GABA A receptors than at 122L and 12 GABA A receptors, potentially impacting anxiolysis and sedation pathways

2005·40citations·Belinda J. Hall et al.·European Journal of Pharmacology

European Journal of Pharmacology