Paper

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors.

Published Aug 1, 2010 · Jiaqiang Cai, M. Baugh, D. Black

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile analogues are potent and selective cathepsin S inhibitors with a stable thio-trapping nitrile war-head compared to other cathepsin inhibitors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors.

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