7-Aminoquinolines. A novel class of agents active against herpesviruses.

doi:10.1021/JM00402A016

Paper

7-Aminoquinolines. A novel class of agents active against herpesviruses.

Published Jul 1, 1988 · M. Nasr, J. Drach, S. Smith

Journal of medicinal chemistry

34

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Abstract

A series of 7-aminoquinoline derivatives was synthesized and evaluated for their capacity to produce cytotoxicity in KB cells and to inhibit the replication of herpes simplex virus (HSV) type 1. All compounds tested inhibited the replication of HSV-1 with 50% inhibitory concentrations in the range of 2-50 micrograms/mL. The antiviral activity of many compounds, however, was separated from cytotoxicity to replicating uninfected cells by only two- to fivefold higher than those required for antiviral activity. Nonetheless, six compounds (10, 28, 29, 32, 34, and 36) were identified in which the separation was greater than fivefold. All compounds examined were more potent inhibitors of viral DNA synthesis than the cellular DNA synthesis.

In Vitro Study

Study Snapshot

7-aminoquinolines show potential as a novel class of agents against herpesviruses, with some showing greater than fivefold antiviral activity compared to cytotoxicity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

7-Aminoquinolines. A novel class of agents active against herpesviruses.

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